Kratom for fatigue

There isn’t a wealth of high-quality research specifically on Kratom for fatigue. However, here’s some information to consider:

  • Anecdotal Evidence: Many users report using Kratom to combat fatigue, and some studies touch on this. A study published in Taylor & Francis Online [] found that nearly half (49%) of regular Kratom users reported using it for fatigue or to boost stamina.

  • Potential Mechanisms: Kratom’s active compounds, mitragynine and 7-hydroxymitragynine, affect opioid receptors. Opioid receptors play a role in pain perception and mood regulation, which could indirectly influence energy levels.


However, there are some key points to consider:

  • Lack of Robust Studies: The research on Kratom and fatigue is mostly anecdotal or based on small studies. Large-scale, well-designed trials are needed to confirm Kratom’s effectiveness for fatigue and determine optimal dosages.
  • Double-Edged Sword: Kratom can have stimulating effects at lower doses, potentially helping with fatigue. However, higher doses can be sedating, potentially worsening fatigue.
  • Withdrawal: Studies suggest regular Kratom use can lead to withdrawal symptoms, including fatigue, when use is stopped.


While some people use Kratom for fatigue, and it might have some stimulating properties at low doses, there’s a lack of strong scientific evidence. Considering the potential risks of Kratom, it’s not a recommended solution for fatigue without consulting a doctor.

Kratom is not currently regulated by the FDA and can be contaminated with other substances.  FDA continues to monitor kratom and raise concerns about its safety and potential for abuse. It recently reiterated its stance that kratom is not a safe or effective dietary supplement. Consulting a healthcare professional before using kratom is essential for responsible and safe pain management.

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